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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Amos Rusie | 548.0 | 1890 | |
| 2 | Amos Rusie | 532.0 | 1892 | |
| 3 | Kid Gleason | 506.0 | 1890 | |
| 4 | Amos Rusie | 500.0 | 1891 | |
| 5 | Amos Rusie | 482.0 | 1893 | |
| 6 | Gus Weyhing | 469.0 | 1892 | |
| 7 | Gus Weyhing | 466.0 | 1887 | |
| 8 | Bert Cunningham | 453.0 | 1888 | |
| 8 | Cy Young* | 453.0 | 1892 | |
| 8 | Kid Nichols* | 453.0 | 1892 | |
| 11 | Gus Weyhing | 450.0 | 1891 | |
| 12 | Gus Weyhing | 449.0 | 1889 | |
| 13 | Ted Breitenstein | 447.0 | 1894 | |
| 13 | Elmer Smith | 447.0 | 1887 | |
| 15 | Pink Hawley | 444.0 | 1895 | |
| 15 | Amos Rusie | 444.0 | 1894 | |
| 17 | Ted Breitenstein | 429.0 | 1895 | |
| 18 | Kid Nichols* | 425.0 | 1891 | |
| 18 | Kid Nichols* | 425.0 | 1893 | |
| 20 | Kid Nichols* | 424.0 | 1890 | |
| 21 | Cy Young* | 423.0 | 1891 | |
| 21 | Jesse Tannehill | 423.0 | 1901 | |
| 23 | Cy Young* | 422.0 | 1893 | |
| 24 | Kid Gleason | 418.0 | 1891 | |
| 25 | Kid Carsey | 415.0 | 1891 | |
| 26 | Cy Young* | 414.0 | 1896 | |
| 26 | Frank Foreman | 414.0 | 1889 | |
| 28 | Bill Dinneen | 413.0 | 1901 | |
| 29 | Cy Young* | 410.0 | 1901 | |
| 29 | Noodles Hahn | 410.0 | 1901 | |
| 31 | Roy Patterson | 409.0 | 1905 | |
| 32 | Cy Young* | 408.0 | 1894 | |
| 32 | Vic Willis | 408.0 | 1901 | |
| 34 | Kid Nichols* | 407.0 | 1894 | |
| 35 | Christy Mathewson* | 404.0 | 1901 | |
| 35 | Gus Weyhing | 404.0 | 1888 | |
| 37 | Mike O'Neill | 400.0 | 1901 | |
| 37 | Kid Gleason | 400.0 | 1892 | |
| 39 | Doc White | 399.0 | 1901 | |
| 40 | Rube Waddell* | 397.0 | 1901 | |
| 41 | Kid Nichols* | 396.0 | 1901 | |
| 41 | Frank Kitson | 396.0 | 1901 | |
| 41 | Deacon Phillippe | 396.0 | 1901 | |
| 44 | Pete Dowling | 393.0 | 1901 | |
| 44 | Amos Rusie | 393.0 | 1895 | |
| 44 | Eddie Plank* | 393.0 | 1901 | |
| 47 | Pink Hawley | 392.0 | 1894 | |
| 47 | Tom Hughes | 392.0 | 1901 | |
| 49 | Jack Cronin | 391.0 | 1901 | |
| 50 | Case Patten | 390.0 | 1901 | |
| 50 | Gus Weyhing | 390.0 | 1890 | |
| 52 | Kid Nichols* | 388.0 | 1898 | |
| 53 | Ned Garvin | 387.0 | 1901 | |
| 53 | Ed Doheny | 387.0 | 1901 | |
| 53 | Jack Powell | 387.0 | 1901 | |
| 53 | Roy Patterson | 387.0 | 1901 | |
| 53 | Dummy Taylor | 387.0 | 1901 | |
| 58 | Doc Newton | 386.0 | 1901 | |
| 59 | Al Orth | 384.0 | 1901 | |
| 60 | Brickyard Kennedy | 382.0 | 1893 | |
| 60 | George Winter | 382.0 | 1901 | |
| 60 | Ted Breitenstein | 382.0 | 1893 | |
| 63 | Kid Gleason | 380.0 | 1893 | |
| 63 | Bill Donovan | 380.0 | 1901 | |
| 65 | Kid Nichols* | 379.0 | 1895 | |
| 65 | Bill Phillips | 379.0 | 1901 | |
| 65 | Watty Lee | 379.0 | 1901 | |
| 65 | Sam Leever | 379.0 | 1899 | |
| 69 | Jose Mendez* | 378.0 | 1908 | |
| 69 | Cy Young* | 378.0 | 1908 | |
| 69 | Pink Hawley | 378.0 | 1896 | |
| 72 | Cy Young* | 377.0 | 1898 | |
| 72 | Fred Toney | 377.0 | 1917 | |
| 74 | Ed Walsh* | 376.0 | 1912 | |
| 74 | George Cuppy | 376.0 | 1892 | |
| 76 | Doc McJames | 374.0 | 1898 | |
| 77 | Jock Menefee | 373.0 | 1901 | |
| 77 | Jack Powell | 373.0 | 1899 | |
| 79 | Kid Nichols* | 372.0 | 1896 | |
| 80 | Walter Johnson* | 370.0 | 1915 | |
| 80 | Slim Sallee | 370.0 | 1912 | |
| 82 | Hippo Vaughn | 369.0 | 1915 | |
| 82 | Frank Smith | 369.0 | 1908 | |
| 82 | Cy Young* | 369.0 | 1895 | |
| 82 | Slim Sallee | 369.0 | 1913 | |
| 82 | Cy Young* | 369.0 | 1899 | |
| 87 | Mordecai Brown* | 368.0 | 1908 | |
| 87 | Slim Sallee | 368.0 | 1910 | |
| 87 | Kid Nichols* | 368.0 | 1897 | |
| 87 | Jay Hughes | 368.0 | 1901 | |
| 91 | Mordecai Brown* | 367.0 | 1905 | |
| 92 | Ed Walsh* | 366.0 | 1908 | |
| 92 | Addie Joss* | 366.0 | 1908 | |
| 92 | Win Mercer | 366.0 | 1896 | |
| 92 | Joe McGinnity | 366.0 | 1899 | |
| 96 | Walter Johnson* | 365.0 | 1918 | |
| 96 | Cy Falkenberg | 365.0 | 1912 | |
| 96 | Pink Hawley | 365.0 | 1901 | |
| 96 | Jeff Tesreau | 365.0 | 1917 | |
| 100 | Hippo Vaughn | 363.0 | 1917 |
