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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Amos Rusie | 341 | 1890 | |
| 2 | Amos Rusie | 337 | 1891 | |
| 3 | Rube Waddell* | 299 | 1904 | |
| 4 | Amos Rusie | 288 | 1892 | |
| 5 | Rube Waddell* | 279 | 1903 | |
| 6 | Rube Waddell* | 276 | 1901 | |
| 7 | Christy Mathewson* | 266 | 1901 | |
| 8 | Rube Waddell* | 261 | 1905 | |
| 9 | Noodles Hahn | 255 | 1901 | |
| 10 | Eddie Plank* | 251 | 1914 | |
| 11 | Joe Wood | 248 | 1912 | |
| 11 | Rube Waddell* | 248 | 1906 | |
| 13 | Tom Hughes | 245 | 1901 | |
| 13 | Walter Johnson* | 245 | 1911 | |
| 13 | Walter Johnson* | 245 | 1912 | |
| 16 | Red Ames* | 243 | 1904 | |
| 16 | Bill Donovan | 243 | 1901 | |
| 18 | Doc White | 242 | 1901 | |
| 19 | Joe Wood | 240 | 1911 | |
| 19 | Kid Nichols* | 240 | 1891 | |
| 21 | Cy Seymour* | 239 | 1898 | |
| 22 | Hooks Wiltse | 238 | 1904 | |
| 22 | Joe Wood | 238 | 1913 | |
| 24 | Rube Marquard | 237 | 1911 | |
| 25 | Ad Lankford | 231 | 1919 | |
| 26 | Red Ames* | 229 | 1905 | |
| 26 | Ed Walsh* | 229 | 1911 | |
| 28 | Ed Walsh* | 227 | 1912 | |
| 28 | Charles Bender* | 227 | 1905 | |
| 30 | Jose Mendez* | 225 | 1910 | |
| 31 | Kid Nichols* | 222 | 1890 | |
| 31 | Kid Gleason | 222 | 1890 | |
| 33 | Dazzy Vance | 221 | 1923 | |
| 33 | Rube Marquard | 221 | 1910 | |
| 33 | Walter Johnson* | 221 | 1914 | |
| 33 | Rube Waddell* | 221 | 1907 | |
| 33 | Rube Waddell* | 221 | 1908 | |
| 38 | Ed Walsh* | 220 | 1910 | |
| 39 | Gus Weyhing | 219 | 1891 | |
| 40 | Rube Waddell* | 218 | 1902 | |
| 40 | Walter Johnson* | 218 | 1910 | |
| 42 | Vean Gregg | 217 | 1911 | |
| 43 | Jose Mendez* | 214 | 1908 | |
| 44 | Gus Weyhing | 213 | 1889 | |
| 45 | Christy Mathewson* | 212 | 1904 | |
| 45 | Walter Johnson* | 212 | 1913 | |
| 47 | Christy Mathewson* | 210 | 1908 | |
| 47 | Dazzy Vance | 210 | 1928 | |
| 49 | Walter Johnson* | 208 | 1915 | |
| 49 | Amos Rusie | 208 | 1893 | |
| 49 | Cy Falkenberg | 208 | 1912 | |
| 52 | Claude Hendrix | 207 | 1912 | |
| 52 | Vean Gregg | 207 | 1912 | |
| 54 | Christy Mathewson* | 206 | 1905 | |
| 54 | Russ Ford | 206 | 1910 | |
| 56 | Eddie Plank* | 205 | 1905 | |
| 57 | Frank Lange | 204 | 1911 | |
| 57 | Orval Overall | 204 | 1910 | |
| 57 | Gus Weyhing | 204 | 1888 | |
| 57 | Hippo Vaughn | 204 | 1914 | |
| 61 | Fred Beebe | 203 | 1906 | |
| 61 | Harry Krause | 203 | 1910 | |
| 63 | Rube Marquard | 202 | 1912 | |
| 63 | Vic Willis | 202 | 1901 | |
| 63 | Gus Weyhing | 202 | 1892 | |
| 63 | Dazzy Vance | 202 | 1924 | |
| 63 | Dutch Leonard | 202 | 1914 | |
| 68 | Charles Bender* | 201 | 1908 | |
| 68 | Amos Rusie | 201 | 1895 | |
| 70 | Joe Wood | 200 | 1910 | |
| 70 | Willie Mitchell | 200 | 1914 | |
| 72 | Jose Mendez* | 199 | 1907 | |
| 72 | Christy Mathewson* | 199 | 1909 | |
| 72 | Harry Howell | 199 | 1905 | |
| 75 | Cy Young* | 198 | 1905 | |
| 75 | Frank Smith | 198 | 1908 | |
| 77 | Charles Bender* | 197 | 1910 | |
| 77 | Jack Pfiester | 197 | 1906 | |
| 77 | Red Ames* | 197 | 1908 | |
| 80 | Amos Rusie | 195 | 1894 | |
| 80 | Christy Mathewson* | 195 | 1903 | |
| 80 | Dutch Leonard | 195 | 1915 | |
| 83 | Hippo Vaughn | 194 | 1913 | |
| 83 | Walter Johnson* | 194 | 1908 | |
| 85 | Grover Cleveland Alexander* | 193 | 1917 | |
| 85 | Gus Weyhing | 193 | 1887 | |
| 85 | Bob Feller# | 193 | 1940 | |
| 88 | Charles Bender* | 192 | 1909 | |
| 89 | Jeff Tesreau | 191 | 1914 | |
| 89 | Heinie Berger | 191 | 1908 | |
| 89 | Red Ames* | 191 | 1910 | |
| 89 | Joe Wood | 191 | 1914 | |
| 93 | Harry Krause | 190 | 1909 | |
| 93 | Red Ames* | 190 | 1906 | |
| 93 | Ed Walsh* | 190 | 1905 | |
| 96 | Guy Morton | 189 | 1914 | |
| 97 | Charles Bender* | 188 | 1913 | |
| 97 | Orval Overall | 188 | 1908 | |
| 97 | Frank Lange | 188 | 1910 | |
| 100 | Jack Coombs | 187 | 1910 |
