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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | W | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Cy Young* | 513 | 1890-1911 | |
| 2 | Walter Johnson* | 423 | 1907-1927 | |
| 3 | Joe Williams* | 404 | 1907-1930 | |
| 4 | Kid Nichols* | 394 | 1890-1906 | |
| 5 | Bill Foster* | 358 | 1923-1949 | |
| 6 | Satchel Paige | 352 | 1927-1951 | |
| 7 | Charles Bender* | 345 | 1903-1924 | |
| 8 | Ray Brown | 339 | 1931-1953 | |
| 9 | Eddie Plank* | 337 | 1901-1917 | |
| 10 | Christy Mathewson* | 328 | 1900-1916 | |
| 11 | Grover Cleveland Alexander* | 321 | 1911-1930 | |
| 12 | Lefty Grove* | 311 | 1925-1945 | |
| 13 | Ed Brandt | 299 | 1928-1950 | |
| 14 | Red Ames* | 294 | 1903-1919 | |
| 15 | Carl Hubbell* | 292 | 1928-1948 | |
| 16 | Eddie Cicotte* | 290 | 1906-1923 | |
| 17 | Eppa Rixey | 282 | 1912-1933 | |
| 18 | Babe Adams* | 280 | 1906-1926 | |
| 19 | Rube Marquard | 273 | 1908-1925 | |
| 20 | Andy Cooper | 270 | 1920-1942 | |
| 21 | Dick Redding | 267 | 1911-1931 | |
| 22 | Larry French | 266 | 1929-1953 | |
| 22 | Jack Powell | 266 | 1897-1912 | |
| 24 | Luis Tiant Sr. | 264 | 1926-1951 | |
| 24 | Gus Weyhing | 264 | 1887-1901 | |
| 26 | Hilton Smith | 260 | 1932-1952 | |
| 27 | Martin Dihigo | 258 | 1924-1946 | |
| 28 | Waite Hoyt | 254 | 1919-1944 | |
| 29 | Bob Shawkey | 253 | 1913-1927 | |
| 30 | Leroy Matlock | 251 | 1929-1952 | |
| 31 | Jose Mendez* | 249 | 1907-1926 | |
| 31 | Van Mungo# | 249 | 1931-1954 | |
| 33 | Amos Rusie | 246 | 1889-1901 | |
| 34 | Henry McHenry# | 241 | 1931-1954 | |
| 35 | Bill Doak | 239 | 1913-1929 | |
| 36 | William Bell | 238 | 1923-1942 | |
| 37 | Red Faber | 237 | 1914-1932 | |
| 38 | Paul Derringer | 236 | 1931-1952 | |
| 39 | Spud Chandler | 235 | 1937-1952 | |
| 40 | Clark Griffith | 234 | 1891-1911 | |
| 41 | Red Ruffing | 233 | 1924-1946 | |
| 42 | Dutch Leonard | 232 | 1913-1925 | |
| 42 | Jack Quinn | 232 | 1909-1932 | |
| 44 | Bob Feller# | 229 | 1936-1954 | |
| 45 | Barney Brown | 221 | 1931-1952 | |
| 45 | Carl Mays | 221 | 1915-1929 | |
| 47 | Bill Donovan | 220 | 1898-1918 | |
| 47 | Herb Pennock | 220 | 1912-1934 | |
| 49 | Addie Joss* | 217 | 1902-1910 | |
| 50 | Roosevelt Davis | 216 | 1924-1950 | |
| 50 | Bill Holland | 216 | 1919-1941 | |
| 50 | Art Nehf | 216 | 1915-1929 | |
| 53 | Rube Waddell* | 215 | 1897-1910 | |
| 53 | Ed Walsh* | 215 | 1904-1914 | |
| 55 | Mordecai Brown* | 214 | 1903-1916 | |
| 56 | Freddie Fitzsimmons | 212 | 1925-1941 | |
| 57 | Burleigh Grimes | 211 | 1916-1934 | |
| 57 | Webster McDonald | 211 | 1922-1940 | |
| 59 | Schoolboy Rowe# | 210 | 1933-1954 | |
| 60 | Dolf Luque | 209 | 1914-1935 | |
| 60 | Vic Willis | 209 | 1898-1910 | |
| 62 | Doc White | 206 | 1901-1912 | |
| 63 | Tex Carleton | 205 | 1932-1951 | |
| 63 | Pat Malone | 205 | 1928-1947 | |
| 65 | Jesse Haines | 202 | 1919-1938 | |
| 66 | Leon Day# | 201 | 1935-1954 | |
| 67 | Al Orth | 200 | 1895-1909 | |
| 68 | Jesse Tannehill | 199 | 1894-1910 | |
| 69 | Barney Morris | 198 | 1932-1947 | |
| 70 | Lon Warneke | 195 | 1930-1949 | |
| 71 | Terris McDuffie | 193 | 1930-1950 | |
| 71 | Roy Partlow# | 193 | 1934-1954 | |
| 71 | Slim Sallee | 193 | 1908-1921 | |
| 74 | Sam Jones | 191 | 1916-1935 | |
| 75 | Claude Hendrix | 190 | 1911-1920 | |
| 75 | Deacon Phillippe | 190 | 1899-1911 | |
| 77 | Porter Moss# | 189 | 1932-1954 | |
| 77 | Ted Trent | 189 | 1927-1949 | |
| 77 | Dazzy Vance | 189 | 1921-1935 | |
| 80 | Brickyard Kennedy | 188 | 1892-1903 | |
| 80 | Hippo Vaughn | 188 | 1909-1921 | |
| 82 | Stan Coveleski | 187 | 1915-1928 | |
| 83 | Sam Streeter | 186 | 1921-1936 | |
| 84 | Harry Howell | 185 | 1898-1909 | |
| 85 | Bullet Rogan* | 184 | 1915-1934 | |
| 86 | Rube Benton | 182 | 1911-1925 | |
| 86 | Bob Ewing | 182 | 1902-1910 | |
| 88 | Mel Harder# | 181 | 1929-1954 | |
| 88 | Pink Hawley | 181 | 1892-1901 | |
| 90 | Jack Chesbro | 180 | 1899-1909 | |
| 90 | Lee Grissom | 180 | 1934-1953 | |
| 92 | Wilbur Cooper | 178 | 1912-1926 | |
| 93 | Bill Byrd | 176 | 1932-1951 | |
| 93 | Joe McGinnity | 176 | 1899-1908 | |
| 95 | Earl Moore | 175 | 1901-1913 | |
| 95 | Roy Welmaker | 175 | 1933-1952 | |
| 97 | Bill Dinneen | 173 | 1898-1909 | |
| 98 | Lefty Tyler | 172 | 1910-1921 | |
| 98 | Hooks Wiltse | 172 | 1904-1914 | |
| 100 | Dutch Leonard | 169 | 1933-1954 |
